Comet gift vouchers are suspended

4 November 2012 Last updated at 04:33 ET

e4419   63914351 63914346 Comet gift vouchers are suspended
Media requires JavaScript to play.

Comet customer: “It looks like a plague of locusts have been inside [the store] and cleaned the place out”

The administrators of the electrical retailer Comet have suspended the use of gift vouchers at the stores.

The shops have been open as usual over the weekend since administrators were called in on Friday.

The Comet website has returned in a slimmed down form, confirming store locations and answering questions about the administration.

There has been no sign of heavy discounting so far, but the website said a sale would be starting soon.

On the question of gift vouchers, it said: “The administrators are currently considering the position in relation to gift cards and gift vouchers and at this stage they cannot be used to pay for items.

“The administrators are reviewing this position urgently.”

Holders of gift vouchers would usually be considered as low priority creditors to a retailer going into administration, and would be unlikely to be able to use their vouchers.

The exception is when a chain is sold to new owners, who might decide to accept them as an act of goodwill to prevent the brand they have bought being tarnished.

The new website explained on its front page that administrators from Deloitte had been appointed.

Its question and answer section said that people who were waiting for items to be delivered that they had paid for would only be receiving those items if they were already in stock at a delivery centre.

“Where the item for an existing order is not currently in stock, this delivery cannot now be made,” it said.

BBC News – Business
Read More..

Brazil’s ‘pop-star priest’ gets mammoth new stage

























SAO PAULO (AP) — Brazil‘s “pop-star priest” is already packing in the crowds at the newly opened mammoth sanctuary that he built for his campaign to stem the exodus of faithful from the Roman Catholic Church in Latin America’s biggest nation.


Brazil still has more Catholics than any other country in the world, with about 65 percent of its 192 million people identifying themselves that way in the 2010 census. But that is down from 74 percent in 2000 and is the lowest since records began tracking religion 140 years ago.





















That’s where Father Marcelo Rossi‘s Mother of God sanctuary comes in. The not-yet-finished structure will seat 6,000 people and have standing room for 14,000 more, church leaders say. In addition, the grounds outside can hold 80,000 people who could watch Mass on outdoor video screens.


After the inaugural Mass on Friday attracted upward of 50,000 people, a beaming Rossi told reporters: “They couldn’t all fit in. There was a crowd that had to stand outside! That’s a sign we’re on the right path, and it’s this sanctuary.”


Similar numbers jammed into the huge church Saturday.


It’s a fitting stage for Rossi, a Latin Grammy-nominated singer who is known for tossing buckets of holy water on worshippers and performing rollicking Christian songs backed by a blasting live band during Mass.


The church sits on 323,000 square feet (30,000 square meters) of land. Church officials declined to confirm how big the actual building is, though local reports put it at 91,500 square feet (8,500 square meters). That would make it one of the world’s 10 biggest churches. A cross soaring 138 feet (42 meters) into the air is the focal point.


The Mother of God sanctuary is anything but traditional. Designed by noted Brazilian architect Ruy Ohtake, it has a wide-open layout giving it the feel of a warehouse. Concrete walls hold up a sloping blue roof that from the outside looks more like a basketball arena than a house of worship. With the church several years away from completion, white plastic chairs were in the place of pews for a lucky few thousand to grab a seat. The rest had to stand.


Rossi dismisses the idea his huge church is a response to the explosion of the evangelical Christian faith in Brazil. Rather, the priest seems to be battling what recent studies indicate is Catholicism’s biggest enemy: indifference.


While millions of Brazilian Catholics joined Pentecostal congregations in the 1990s, a study conducted last year by Brazil’s Getulio Vargas Foundation based on census data found that the Catholics leaving the church these days are mostly becoming nonreligious. Experts have said the trend of Brazilians deciding organized religion isn’t for them poses a more potent threat to Catholic leaders than losses to the Pentecostals.


Rossi chose to open his new church on the Brazilian holiday of Finados, the nation’s version of the Day of the Dead. “A day, a day that was dead, was transformed!” the priest told worshippers during the service, using his gold-plated microphone.


The “pop-star priest” is seen by Brazilian Catholicism as its biggest weapon against the lack of interest, and his new sanctuary adds to his tools of best-selling books and music recordings to keep worshippers interested in what many complain has become a staid institution.


There was nothing stale about his Mass on Friday.


Singing as loud as they could, waving white hankies and swaying with a rocking band, the 20,000 people who jammed into the Mother of God sanctuary hammed it up for TV cameras and shed tears down their cheeks as their superstar priest waved to them from the pulpit. An estimated 30,000 other people had gathered outside, where young boys climbed up into nearby trees trying to get a glimpse of the church grounds as they squinted over a sea of heads streaming out of the sanctuary.


“We have problems, everyone has problems,” worshipper Zuleima de Oliveira Sales said as she stood in the tightly packed sea of people under the soaring blue roof of the structure, her voice choking. “They don’t come to an end, but I have faith, I have faith in Our Lady.”


That’s the sort of belief the Catholic Church is counting on in Brazil and other developing nations. Leaders from the Vatican on down are looking to them as bulwarks against losses in Europe and the U.S., where sex abuse scandals have inspired many people to leave the church. About half of the world’s Catholics live in Latin America.


Pentecostalism was once seen as a major threat to Brazil’s Catholic Church. Pentecostal churches, many of them founded by U.S. evangelicals, saw their membership double to more than 12 percent of the country’s population over the 1990s, with about half of the congregants estimated to be former Catholics.


During the 1990s, Brazil’s economy suffered from hyperinflation and other woes, and Pentecostal churches aggressively recruited in the slums and poor outskirts of Brazil’s cities by offering nuts-and-bolts self-improvement advice as well as Christian ministry.


Since 2003, however, Pentecostal churches have seen growth slow. The percentage of Brazilians calling themselves Pentecostals edged up from 12.5 percent of the population to 13.3 percent.


Yet the Catholic Church has continued to lose parishioners, and church leaders have had little success so far in halting that trend.


Brazil was the first nation outside Europe that Pope Benedict XVI visited, during a five-day tour in 2007 largely aimed at stopping losses in Latin America. During the trip, the pope canonized Brazil’s first native-born saint.


Then Benedict announced last August during the church’s World Youth Day, which drew 1.5 million people to Spain, that the next version of the gathering would be held in Rio de Janeiro in 2013. The pope is expected to attend.


For now, Rossi hopes his big church will bring together tens of thousands of faithful for every Mass, giving new energy to the Catholic faith.


“People want big spaces. They want grand places for prayer,” he told the Globo TV network. “One candle illuminates, 10 candles illuminate — and 100,000 candles light up so much more.”


Latin America News Headlines – Yahoo! News



Read More..

13 Gadgets to Prepare You for a Natural Disaster

























1. Wind-Up Radio


Radios may seem like primitive technology in the digital age, but they’re still very effective in relaying information during an emergency. The one pictured uses solar power, features a hand-crank for backup power and even includes a flashlight.


Click here to view this gallery.





















[More from Mashable: Yoink Crowdsources Aid After Sandy]


Earlier this week, Hurricane Sandy hit the East Coast of the United States as well as Caribbean countries, leaving tremendous disaster in its wake. People have gone without power for days, and the elderly and disabled — especially those in high-rise buildings — are unable to get the food and water they need.


[More from Mashable: NYC Marathon Canceled Amid Online Backlash]


Many of these people prepared for the storm, but due to Sandy’s magnitude, weren’t able to imagine its tragic aftermath.


We compiled a short list of tech essentials that could help you prepare for storms and natural disasters beyond Sandy, especially when a generator is either too expensive or isn’t plausible for your living situation. Of course, these items should be considered in addition to fundamental precautions and supplies, which include enough water and food to last at least three to seven days, a first aid kit, extra batteries and gasoline.


What kind of tech have you found useful in your disaster or emergency preparedness kit? Let us know in the comments.


[wp_scm_hurricane_sandy]


This story originally published on Mashable here.


Tech News Headlines – Yahoo! News



Read More..

Amy Winehouse wedding dress stolen: family foundation

























LONDON (Reuters) – Two dresses worn by late British singer Amy Winehouse have been stolen from her house, her family’s charitable foundation told Reuters on Thursday.


The two dresses were due to be auctioned as part of charity events later this year and next in London and New York to raise money for The Amy Winehouse Foundation, which funds a number of concerns including children’s hospices and drug counseling.





















One of the Back to Black singer’s stolen frocks was the dress she wore to marry Blake Fielder-Civil in 2007 and the other was a newsprint cocktail dress. Both were taken from a cupboard in her house after they had been catalogued alongside other items.


The foundation said the house had not been broken into and that a formal complaint to police was forthcoming.


The workers who catalogued the dresses after Winehouse’s death had packed them away in a cupboard and discovered two were missing when they later returned to check on the wardrobe.


“It’s got to be someone with access to the house,” a spokesman for the foundation said.


Amy’s father Mitch Winehouse was quoted in London’s Evening Standard newspaper as saying that he was “baffled” why thieves had not gone for her designer dresses.


“It’s sickening that someone would steal something in the knowledge of its sentimental value,” he said.


Amy Winehouse was found dead in her London home on July 23, 2011, at the age of 27 from what officials later determined was accidental alcohol poisoning. There were no illicit drugs in her system.


Fielder-Civil and Winehouse had a turbulent relationship, punctuated by violent fights and reports of heavy use of cocaine, heroin and ecstasy. They were married for about two years until 2009. He also served six months in prison stemming from an 2007 assault on a London pub landlord.


The “Rehab” singer’s ex-husband was put on life support in a British hospital in August after an apparent drink and drug binge.


Winehouse’s family have said that their daughter beat her drug dependency about three years before her death.


(Reporting by Paul Casciato, editing by Jill Serjeant and Patricia Reaney)


Music News Headlines – Yahoo! News



Read More..

Watch: Cancer Touches Everyone: Dogs and Humans

























Home > Video > Health > Health News



Cancer Touches Everyone: Dogs and Humans





















Cancer Touches Everyone: Dogs and Humans


Two Million Dogs hopes to eradicate cancer through education and research.




Magic Johnson’s HIV Announcement: Nov. 7, 1991


Magic Johnson’s HIV Announcement: Nov. 7, 1991


Los Angeles Lakers’ star holds press conference to say he will retire immediately.




Anorexic Baker Raises Money for Treatment


Anorexic Baker Raises Money for Treatment


Washington woman with an eating disorder sells cookies online to raise funds for medical attention.




Flood Water Test Results


Flood Water Test Results


Dr. Richard Besser shares findings on the safety of the flood waters brought by Sandy.




Superstorm Sandy: Babies from NYU Hospital Rescued


Superstorm Sandy: Babies from NYU Hospital Rescued


The NYU Medical Center in Manhattan was evacuated after a power outage during the storm.




Cooking Without Power after Superstorm Sandy


Cooking Without Power after Superstorm Sandy


A look at what you can make without modern conveniences and if you will have enough to survive.




What is in the Flood Waters Left by Superstorm Sandy?


What is in the Flood Waters Left by Superstorm Sandy?


Dr. Richard Besser explains what exactly is in flood waters and how to stay safe.




Superstorm Sandy: How to Cope when Cooped Up


Superstorm Sandy: How to Cope when Cooped Up


Dr. Janet Taylor discusses various ways to keep your kids and yourself from going stir crazy.




Superstorm Sandy: NYU Hospital Evacuated in New York


Superstorm Sandy: NYU Hospital Evacuated in New York


David Muir reports on s city hospital where the power has failed.




Superstorm Sandy Storm Surge in New York City


Superstorm Sandy Storm Surge in New York City


Chris Cuomo reports on the aftermath of the storm in the Big Apple.




How to Talk Kids about Hurricane Sandy


How to Talk Kids about Hurricane Sandy


Dr. Janet Taylor discusses tips to make children aware of the severity of the storm.




5 Things You Need to Survive Hurricane Sandy


5 Things You Need to Survive Hurricane Sandy


Dr. Besser outlines the 5 necessities needed to battle serious health hazards from the superstorm.



Health News Headlines – Yahoo! News



Read More..

Anthony Scianna’s Storybook Ending

























a11e5  etc openerfairytale45  02  inline202 Anthony Sciannas Storybook EndingFrancesco Nazardo for Bloomberg BusinessweekA typical Friday night at FairyTail Lounge


To enter the FairyTail Lounge, a one-year-old New York nightclub opened by three former commodities traders, guests pass through a sparkle-splattered door into a small room so shimmery it looks like it was painted by Tinker Bell. Above the bar, two male garden gnomes perch on an overhead shelf, frozen in ceramic ecstasy, one’s face pressed against the other’s glazed butt.





















a11e5  etc openerfairytale45  01  inline202 Anthony Sciannas Storybook EndingFrancesco Nazardo for Bloomberg Businessweek


On a dank Saturday night, the only things more dazzling than the bar itself are Roxy Brooks and Lauren Ordair, two drag queens bedecked with enough costume jewelry to sink a pirate ship. “It’s just terrible what happened to those people,” says Ordair, referring to the nearly 1,000 commodities traders who’ve lost their jobs over the last two years. “But it’s happening everywhere. Drag wasn’t my first choice, you know. I studied to be an opera singer. Turns out it’s a small field.” Now the tenor soprano belts out show tunes at FairyTail on Mondays, where one of those laid-off traders, her boss, has just arrived.


“Anthony!” the drag queen suddenly chimes, Cheers-style, as she waves to the bar’s proprietor, Anthony Scianna, a 50-year-old wearing a zip-up cardigan. If Scianna’s job hadn’t been made obsolete, the FairyTail Lounge might be nothing more than fantasy.


Once upon a time, not so very long ago, a pauper could become a prince if he knew the right person. A reliable guy like Scianna, from a working-class family on Staten Island, didn’t need an MBA, or even a college education, to make good money fast as a floor trader. Moving soft commodities such as cotton, coffee, cocoa, sugar, and frozen concentrated orange juice was an old-school apprenticeship: There was no employment office, no interview, just guys who knew guys. All a pauper needed was a loud voice, a sky-high tolerance for stress, and a friend to vouch for him. Scianna got invited to the ball and worked the business for 20 years, from 1990 until last fall, when it became clear that Cinderella’s clock was going to strike midnight any minute.


As recently as early 2011, 90 percent of soft-commodity options were traded on the floor in an open-outcry tradition—a loud, brash system of hand signals, shouts, and frenzied person-to-person deal- making—going back roughly 142 years. But as electronic trading exploded, that percentage has flipped: About 1,000 traders used to work the floor; that number was down to 100 by Oct. 19, when IntercontinentalExchange (ICE) (ICE) closed its floor altogether and completed the transition to computerized trading. It’s an historic shift in the way business gets done and a clear-cut case of humans being replaced by machines. As the system grows more efficient, these jobs are disappearing, and so goes a tribe of Wall Street.


“I had a beautiful life. It was a beautiful experience,” Scianna says in his New York accent, the day after those layoffs left many of his old friends unemployed. “When I would walk into work, it felt like going home. We really were one big beautiful family.” A beautiful family from whom he hid that he was gay for 15 years, but more on that later.


Leaning against a pile of purple velvet pillows, Scianna says he liked the money, the camaraderie, the Cipriani parties, and the great hours: After coffee trading closed at 1:30 p.m., the rest of his day was free. And he thrived on the stress. “It never made me nervous, it made me excited,” he says. “One time, I witnessed a wonderful man, the father of a dear friend, pass away in the ring, trading copper. They just pulled him out and it kept going. The market never stopped.”


Scianna spent two decades trading futures but never thought much about his own. “Then we watched the business go from what it was to nothing. Suddenly the guy next to you was gone,” he says. “In 2010 I was 48, and I said to myself, ‘Who’s going to hire me? I don’t have any other skills.’ So I needed an idea.”


The find-yourself chick flick Eat Pray Love is playing on the TV above the bar, muted, as Scianna explains that he, like Julia Roberts, began his own second act after a bad breakup. A friend told him he had to get back out there, so Scianna hit Manhattan’s gay club scene. “I noticed every single gay bar was always packed,” he says. “All night long.”


This was a growth business with a future: Bartenders, go-go dancers, and drag queens would not be replaced by machines, at least not any time soon. So Anthony pitched his idea for the FairyTail Lounge to two fellow ICE traders, Joe Carman and Dave Dwyer, who looked over the numbers and signed on as investors in the fall of 2010. Scianna immediately quit his job trading coffee for Chicago-based SMW Trading.


When SMW closed down his old division three months later, Scianna was already at work renovating a space at 48th Street and 10th Avenue, with mixed results. Veteran gay club party promoter Joseph Israel, a flashy Puck on the nightlife circuit, says Scianna’s original bar design was too, well, “ugh.” So he persuaded Scianna to allow him to queer up the place. “The bar was plain, plain, plain,” says Israel with a shiver. “The decoration didn’t even have a fairy tale theme!” So Israel conceived a wonderland of unicorns, satyrs, glitter, and a black-light poster that stars Walt Disney’s (DIS) Prince Charming as a foot fetishist and Snow White being pleased by all seven dwarves.


In a way, it’s not surprising that Scianna’s original idea for the bar was more subdued. He’d spent most of his adult life on conservative Wall Street, where almost everyone was straight—or acted like it. No matter how much he loved his job, he spent about the first 15 years of his career afraid that the more powerful old-timers would find out he was gay and fire him.


“You couldn’t take that chance,” he says, as a slender DJ with a flat-top begins spinning house music in a tiny booth. “You have to realize, Wall Street was a private club for very wealthy people. So I never led anybody to believe that I was gay. In those early days, I didn’t want anyone to have a reason to get rid of me.” He finally came out to co-workers after Sept. 11. “I said, ‘This is who I am. I’m not going to change or come in with a dress on.’ And a lot of the old-timers were gone by then, so it was OK.”


Scianna’s still working in a loud, noisy room filled almost entirely with competitive men who aggressively swap digits. Only instead of bulls and bears, it’s centaurs and unicorns. And instead of waking up at 5 a.m. to make the commute from Staten Island to Wall Street, he’s getting home from the bar around 5:30 a.m., dusted with sparkles. He has new responsibilities as a bar owner—employees, vendors, the glitter supply—but it’s working. When his friend Joanne Cassidy lost her job as a clerk in the ICE layoffs after 20 years on the floor, Scianna was able to give her work as a coat-check girl to tide her over. “There’s a family feeling to the place,” says Cassidy. “It’s like Cheers.”


Scianna says he’s definitely happier, but he sometimes misses the respect, the macho glitz, the big bonuses. “Trading, you could be an a– –hole, you could be cocky,” he says. “You didn’t make money one day? F– – – you, you’d make it tomorrow. Here, I have to take care of so many people.”


“I almost wish I didn’t taste it,” he says of Wall Street. “It’s like the pauper who tastes what it’s like to be rich—the instant gratification of knowing exactly how much money you made every day at 2:30. I’m all right now, but there are employees to pay, vendors, staffing issues. I don’t know how much I’ve made till I pay all the bills.” Scianna is figuring it all out as he goes.


It’s getting close to midnight—almost time for free shots!—and as the go-go boy writhes, the dance floor fills up with handsome young men and Julia Roberts shoves pasta into her face on the bar television. Scianna smiles. Maybe he hasn’t found his happily ever after, but, he says, “it’s a totally whole new life. This is my second act.”


a11e5  etc openerside45 405 Anthony Sciannas Storybook Ending


Businessweek.com — Top News



Read More..

Blake Shelton pulls off surprise win at CMAs

























NASHVILLE, Tenn. (AP) — Winning the Country Music Association Awards’ entertainer of the year is a top honor and always counted as a career high point. But for Blake Shelton it wasn’t even the most memorable moment of an amazing Thursday night.


“The Voice” star took home three trophies, including his third straight male vocalist victory, but nothing compared to sharing song of the year with wife Miranda Lambert. The pair wrote “Over You,” about the death of Shelton‘s brother Richie in a car wreck 15 years ago. He said that trophy will always have a special place in their Oklahoma home.





















“For me as a songwriter that is as personal as I can get,” Shelton said. “So that songwriter award, song of the year award, it will have its own shelf. It will have spotlights on it and an alarm and everything. Trip wires and there will be a land mine if you walk towards it. It is a real big deal to Miranda and I.”


Shelton’s entertainer win was the biggest surprise of a night full of them. Even he couldn’t believe he’d won the award in a field that included Taylor Swift, Jason Aldean, Kenny Chesney and Brad Paisley.


“I didn’t think about that tonight. I was thinking there’s Taylor Swift right there,” he said of the two-time entertainer of the year. “Really, this is pretty dumb that there’s anyone else even nominated.”


The reality, though, is Shelton capped one of the most impressive career reboots in country music history with the win. About three years ago, he was searching for a hit or a gimmick that might return him to the top of the charts, without much luck. He scored a novelty hit with Trace Adkins called “Hillbilly Bone,” began a run of hits and then joined “The Voice” in a move that made him an instant celebrity outside the country world.


He hasn’t sold as many records as Swift, whose “Red” just moved 1.2 million copies in its first week, or as many concert tickets as Chesney or Aldean. But his leading-man looks, wicked sense of humor, Twitter presence and mellow baritone have made him one of country’s top stars.


While Shelton didn’t give himself much of a shot, Lambert — who also won her third straight female vocalist of the year award — thought he fit the definition of entertainer of the year after doing a little research.


“I realized that it just meant not only touring numbers, not only ticket sales or how much production you have, but the way that you represent country music within a year,” Lambert said. “The media that you do and the work that you do and the TV shows that you are on and how you represent yourself and how you speak out about country music. When you think about it that way, Blake Shelton deserved to win that trophy tonight.”


Shelton’s victory was just one of many surprises during the awards. Quartet Little Big Town joined Lambert with two wins apiece, taking home vocal group and single of the year for “Pontoon.” And Thompson Square’s Shawna and Keifer Thompson won vocal duo of the year, ending Sugarland’s five-year run in that category.


“Y’all, this has been a 13-year journey,” Karen Fairchild said as members of the group fist-pumped, jumped up and down and shouted on stage. “We’re living proof that if you work really hard and chase your dream, all the good stuff happens and it follows you. Nashville, you made us your band. Thank you for letting us do this.”


Like fellow outsiders LBT, Eric Church felt the love from the CMA’s voters for the first time. He won the prestigious album of the year for his breakthrough record “Chief,” signaling the North Carolina native’s complete acceptance by the country music community.


“I spent a lot of my career wondering where I fit in — too country, too rock,” Church told the crowd. “I want to thank you guys for giving me somewhere to hang my hat tonight.”


The awards went off-script early, and not just for Little Big Town. Thompson Square won in a category that’s been locked up by either Sugarland or Brooks & Dunn 19 of the last 20 years.


“Ever since I was 5 years old, I used to practice in the kitchen with one of my Meemaw’s Mason jars for this moment here,” Shawna Thompson said.


Hunter Hayes won new artist of the year, while Chesney and Tim McGraw won musical event of the year for “Party Like a Rock Star” and Toby Keith won video of the year for “Red Solo Cup.”


Church helped kick off the show by combining forces with Aldean and Luke Bryan. Playing with a large American flag behind them, the trio of performers teamed up on Aldean’s new single “The Only Way I Know” from his new album “Night Train” and earned a standing ovation. Each returned later to play singles, showing how large a market share they now own in country music.


Most of country’s top stars were on hand at Nashville’s Bridgestone Arena for the celebration, with many slated to perform. Swift performed her somber new single “Begin Again” on a set with a picture of the Eiffel Tower and falling leaves in the background. She received an ovation of her own.


Shelton, McGraw and wife Faith Hill, Lady Antebellum and Keith Urban joined together to salute lifetime achievement winner Willie Nelson, ending with a group sing-along of his iconic “On the Road Again.”


Little Big Town performed their winner “Pontoon,” a song that was something of a departure for Fairchild, Kimberly Schlapman, Jimi Westbrook and Phillip Sweet. Produced by Jay Joyce, the song has a sharper groove than LBT’s previous efforts.


In a coincidence, Joyce also produced Church’s “Chief.” The hard edge he brought to both paid off all around.


Church said album of the year, arguably the CMA’s second most prestigious award, was a win that fit right in with his and Joyce’s philosophy.


“I still think in this day and time the only way to really get a fan base is you’ve got to give them more than one chapter of a book,” Church said. “They’ve got to read the whole book.”


___


AP writer Kristin M. Hall in Nashville contributed to this report.


___


Online:


http://cmaworld.com


http://abc.go.com/shows/cma-awards


___


For the latest country music news from the Associated Press: http://twitter.com. Follow AP Music Writer Chris Talbott: http://twitter.com/Chris_Talbott.


Entertainment News Headlines – Yahoo! News



Read More..

Europe approves high-price gene therapy

























LONDON (Reuters) – European officials have approved the Western world’s first gene therapy drug from a small Dutch biotech company, in a milestone for the novel medical technology that fixes faulty genes.


The formal clearance from the European Commission paves the way for a launch next summer of the treatment for an ultra rare genetic disease that will cost around 1.2 million euros ($ 1.6 million) per patient, a new record for pricey modern medicines.





















After more than 20 years of experiments and a series of disappointments, the EU approval of Glybera, which treats the genetic disorder lipoprotein lipase deficiency (LPLD), is a significant boost for the gene therapy field.


Joern Aldag, chief executive of Amsterdam-based uniQure, said more such treatments would follow and argued a high price was justified because gene therapy restored natural body function and did not just offer a short-term fix.


“This provides higher benefit to patients than the classical protein replacement strategy and this is why we think we should be fairly and adequately compensated,” he said in a telephone interview on Friday.


Patients with LPLD, which affects no more than one or two people per million, are unable to handle fat particles in their blood and are at risk of acute and potentially fatal inflammation of the pancreas.


The approval follows a positive recommendation from the European Medicines Agency in July.


The privately owned firm is now working with governments on potential pricing strategies, which are likely to vary from country to country, ahead of the commercial roll-out from the second half of 2013.


Aldag said some countries preferred the idea of a one-off payment at the time of treatment but others were interested in an annuity system, which would probably involve charging around 250,000 euros a year for five years.


That kind of annual charge would put Glybera in a similar price range to expensive enzyme replacement therapies for other rare diseases, such as Cerezyme for Gaucher disease from Sanofi’s Genzyme unit.


UniQure is also preparing to apply for regulatory approval for Glybera in the United States, Canada and other markets.


EARLIER SETBACKS


The idea of treating disease by replacing a defective gene with a working copy gained credence in 1990 with the success of the world’s first gene therapy clinical tests against a rare condition called severe combined immunodeficiency (SCID).


People with SCID – also known as “bubble boy disease” – cannot cope with infections and usually die in childhood.


The field then suffered a major setback when an Arizona teenager died in a gene therapy experiment in 1999 and two French boys with SCID developed leukaemia in 2002.


In China, Shenzhen SiBiono GeneTech won approval for a gene therapy drug for head and neck cancer in 2003 but no products have been approved until now in Europe or the United States.


More recently, some large pharmaceutical companies have also been exploring gene therapy. GlaxoSmithKline, for example, signed a deal in 2010 with Italian researchers to develop a SCID therapy. ($ 1 = 0.7730 euros)


(Reporting by Ben Hirschler; Editing by Helen Massy-Beresford)


Health News Headlines – Yahoo! News



Read More..

Syrian rebels kill 28 soldiers, several executed

























BEIRUT (Reuters) – Anti-government rebels killed 28 soldiers on Thursday in attacks on three army checkpoints around Saraqeb, a town on Syria’s main north-south highway, a monitoring group said.


Some of the dead were shot after they had surrendered, according to video footage. Rebels berated them, calling them “Assad’s Dogs”, before firing round after round into their bodies as they lay on the ground.





















The highway linking the capital Damascus to the contested city of Aleppo, Syria’s commercial center, has been the scene of heavy fighting since rebels cut the road last month. Saraqeb lies about 40 km (25 miles) south of Aleppo


In other developments, China put forward a new initiative to resolve the 19-month-old conflict, including a phased, region-by-region ceasefire and the setting up of a transitional governing body.


A Chinese Foreign Ministry spokesman said Beijing had made the proposal to international peace envoy Lakhdar Brahimi – whose own call for a truce over the Muslim holiday of Eid was largely ignored by both sides.


The United States meanwhile has called for an overhaul of Syria’s opposition leadership, signaling a break with the largely foreign-based Syrian National Council to bring in more credible figures.


A meeting in Qatar next week of foreign powers backing the rebels will be an opportunity to broaden the coalition against President Bashar al-Assad, U.S. Secretary of State Hillary Clinton said in Zagreb on Wednesday.


The United States and its allies have struggled for months to craft a credible opposition coalition, while Assad has counted on the support of Russia, Iran and, to a lesser extent, China. International efforts to end the violence have all foundered.


More than 32,000 people have been killed since protests against Assad, an Alawite who succeeded his late father Hafez in ruling the mostly Sunni Muslim country, first broke out on city streets. The revolt has since degenerated into full-scale civil war, with the government forces relying heavily on artillery and air strikes to thwart the rebels.


CHECKPOINT ATTACKS


The army has lost swathes of land in Idlib and Aleppo provinces but is fighting to control towns along supply routes to Aleppo city, where its forces are fighting in many districts.


The head of the pro-opposition Syrian Observatory for Human Rights, Rami Abdelrahman, said two of the attacked checkpoints at Saraqeb were on the Damascus-Aleppo highway. The third was near a road linking Aleppo with Latakia, a port city still mostly controlled Assad’s forces.


“The rebels will not stay at the checkpoints for long as Syrian warplanes normally bomb positions after rebels move in,” Abdelrahman said.


Five rebels died in the fighting and at least 20 soldiers were killed at the third site, including those shot after surrendering, he said.


The video footage showed a group of petrified men, some bleeding, lying on the ground as rebels walked around, kicking and stamping on their captives.


One of the captured men says: “I swear I didn’t shoot anyone” to which a rebel responds: “Shut up you animal … Gather them for me.” Then the men are shot dead.


Reuters could not independently verify the footage.


The Observatory said the al Qaeda-inspired Jabhat al-Nusra rebel group was responsible for the executions.


Islamist rebel units are growing in prominence in the war – a cause for concern for international powers as they weigh up what kind of support to give the opposition.


U.S. President Barack Obama’s administration has said it is not providing arms to internal opponents of Assad and is limiting its aid to non-lethal humanitarian assistance. It concedes, however, that some of its allies are providing lethal assistance.


Russia and China have blocked three U.N. Security Council resolutions aimed at increasing pressure on the Assad government, leading the United States and its allies to say they could move beyond U.N. structures for their next steps.


China has been strongly criticized by some Arab countries for failing to take a stronger stance on the conflict. Beijing has urged the Assad government to talk to the opposition and take steps to meet demands for political change.


“More and more countries have come to realize that a military option offers no way out, and a political settlement has become an increasingly shared aspiration,” Chinese Foreign Ministry spokesman Hong Lei said in Beijing.


He said China’s new proposal was aimed at building international consensus and supporting peace envoy Brahimi’s mediation efforts.


(Additional reporting by Ayat Basma, Laila Bassam and Dominic Evans in Beirut and Terril Yue Jones in Beijing; Writing by Oliver Holmes; Editing by Angus MacSwan)


World News Headlines – Yahoo! News



Read More..

Flamboyant Megaupload founder unveils file-sharing sequel

























WELLINGTON (Reuters) – Like a good Hollywood sequel, Megaupload is back.


Kim Dotcom, the founder of the shuttered file-sharing site that housed everything from family photos to blockbuster films, on Thursday announced a new online storage service called Mega that will give users direct control – and responsibility – over their files.





















Mega will launch in January 2013, just before the internet entrepreneur is scheduled to face an extradition hearing to the United States where he and other Megaupload operators face charges of online piracy, fraud and money laundering.


In a snub to U.S. prosecutors, the site will not utilize U.S.-based hosting companies as partners in order to avoid being shut down by U.S. authorities.


The U.S. government alleges that Megaupload, once one of the world’s most popular websites, was directly responsible for illegally uploaded content on the site and that it netted $ 175 million from unlawful activities.


“The new Mega will not be threatened by U.S. prosecutors,” Dotcom told Reuters in an interview, adding that he was confident Mega would avoid violating U.S. law.


“The new Mega avoids any dealings with U.S. hosters, U.S. domains and U.S. backbone providers and has changed the way it operates to avoid another takedown,” he said.


ENCRYPTION KEYS


Mega is the follow-up to Megaupload, which was shut down in January this year when New Zealand police helicopters swooped into the flamboyant Dotcom’s mansion outside Auckland to seize computers and other evidence at the request of U.S. authorities.


Users of the new cloud-based service will be able to upload, store and share photos, text files, music and films, encrypt those files and grant access using unique decryption keys.


“You hold the keys to what you store in the cloud, not us,” a statement on the Mega website said.


While the new site will operate faster and boast a bigger storage capacity, the encryption technology marks a major change from Megaupload as Mega operators will not have access to files and will therefore be immune to content liability.


Ensuring that files are not pirated will be the job of content owners, a major change from Megaupload, which the U.S. film industry says was directly responsible for taking down illegally uploaded content.


“Content owners can still remove infringing material and they will even get direct delete access if they agree not to make us responsible for actions of users,” Dotcom said.


Dotcom’s announcement comes just weeks after a U.S. federal judge ruled that Washington’s criminal case against Megaupload will go forward for now.


Dotcom, a German national who holds New Zealand residency, faces an extradition hearing in March even though a New Zealand court ruled that the January raid and seizure were unlawful, while the nation’s spy agency was found to have illegally spied on Dotcom.


Thursday’s announcement was delayed for about one hour after the website was overloaded by users. According to Dotcom, much of the traffic was driven by U.S. authorities.


“FBI agents pressing reload…We see their IP addresses,” he said on his Twitter feed.


(Reporting by Naomi Tajitsu; Editing by Matt Driskill)


Internet News Headlines – Yahoo! News



Read More..